Testing
Trisomy 13, trisomy 18 and trisomy 21, and numerical errors of the sex chromosomes (X and Y) constitute the most common chromosome abnormalities observed at prenatal diagnosis. DNA probes specific…
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Translocation (11;18)(q21;q21) has been associated with extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). Translocation (11;18) leads to the fusion of the apoptosis inhibitor-2 (API2) gene and…
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MGMT Methylation Detection by PCR - send out
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M MYD88
MYD88 L265P mutations are present in the majority of LPL cases include Waldenström’s macroglobulinemia, Mutations are also detected in a low percentage of chronic lymphocytic leukemia (CLL) and diffuse large… MYD88 p. L265P Mutation
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Somatic mutations of codons 515 and 505 in exon 10 of the “myeloproliferative leukemia virus oncogene” (MPL) represent clonal markers in essential thrombocythemia (ET) and primary myelofibrosis (PMF). MPL codon…
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F MYB
This abnormality has been associated with childhood acute lymphoblastic leukemia (ALL), adult ALL, B-cell small lymphocytic lymphoma, atypical chronic lymphocytic leukemia and plasma cell myeloma. FISH can detect this rearrangement… MYB 6q deletion
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A group of pre-leukemic diseases, myeloproliferative disorders are characterized by a clonal expansion of one or more lineages of the myelo-erythroid series of which polycythaemia vera, essential thrombocythaemia and idiopathic…
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Clonal chromosome abnormalities are found at diagnosis in about 60% of patients with de novo MDS and almost 85% of those with AML or secondary MDS. The FISH profile used…
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F MALT1
Translocation (11;18)(q21;q21) has been associated with extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). Translocation (11;18) leads to the fusion of the apoptosis inhibitor-2 (API2) gene and… MALT1 18q21 rearrangement
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Miller-Dieker syndrome is caused by a deletion on the short arm of chromosome 17, specifically a deletion of the LIS1 gene.
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Mixed lineage leukemia (MLL) abnormalities are frequently found in infant leukemias and therapy-related leukemias. The MLL gene encodes a DNA-binding protein that methylates histone H3 lysine 4 (H3K4), and positively…
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