Test Name
MYD88 p. L265P Mutation
Test Code
M MYD88
Synonyms
MYD88 p.L265P
Associations
Lymphoplasmacytic lymphoma (LPL); Waldenström’s macroglobulinemia, chronic lymphocytic leukemia (CLL) ; diffuse large B-cell lymphoma (DLBCL)
CPT Codes
81479
Turnaround Time
10 days
Specimen Requirements
5.0 mL (min. 1.0 mL) whole blood EDTA preferred, heparin whole blood accepted 3.0 mL (min. 1.0 mL) bone marrow aspirate EDTA preferred, heparin accepted
Specimen Stability
EDTA whole blood or bone marrow stable at room temperature (18-25°C)
Storage & Handling
Whole blood and bone marrow ship in a Styrofoam container with a cool pack. (Do not allow cool/refrigerated pack to directly contact sample
Causes for Rejections
Insufficient DNA content; Insufficient specimen volume; Specimen at incorrect temperature; Incorrect anticoagulant
Description
MYD88 L265P mutations are present in the majority of LPL cases include Waldenström’s macroglobulinemia, Mutations are also detected in a low percentage of chronic lymphocytic leukemia (CLL) and diffuse large B-cell lymphoma (DLBCL) cases. Detection of MY
References
- Swerdlow et al. (2016). The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016 May 19;127(20):2375-90
- Insuasti-Beltran G, Gale JM, Wilson CS, Foucar K, Czuchlewski DR. (2015) Significance of MYD88 L265P Mutation Status in the Subclassification of Low-Grade B-Cell Lymphoma/Leukemia. Arch Pathol Lab Med. 2015 Aug;139(8):1035-41
- Landgren O, Tageja N.2014. MYD88 and beyond: novel opportunities for diagnosis, prognosis and treatment in Waldenström’s Macroglobulinemia.Leukemia. Sep;28(9):1799-803
