Testing
The LSI dual break-apart rearrangement probe contains two differently labelled probes on either sides of the breakpoint of the ROS1 gene. ROS1 has multiple fusion partners including but not limited…
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The LSI dual break-apart rearragement probe contains two differently labelled probes on either sides of the breakpoint of the ALK gene. ALK has multiple fusion partners including NPM in anaplastic…
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FP IGH MALT1
Translocation (11;18)(q21;q21) has been associated with extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). Translocation (11;18) leads to the fusion of the apoptosis inhibitor-2 (API2) gene and… IGH/MALT1 t(14;18), paraffin
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This small, multiprobe panel contributes to the distinction of Burkitt’s from large B-cell lymphoma on problematic specimens demonstrating borderline morphologic or immunophenotypic features, limited sample volume, or zero to low…
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Her2/neu, also known as erbB2 or HER2, plays a key role in the regulation of cell growth. HER2 is over expressed through gene amplification in 25-30% of breast cancer patients.…
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Mantle cell lymphoma can be difficult to distinguish morphologically from other B-cell malignant lymphomas. The translocation probe is designed to detect the juxtaposition of the IGH locus (14q32) next to…
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FP HER2 GA
The FDA recently approved trastuzumab (Herceptin, Genentech) for use in combination with cisplatin and capecitabine or 5-fluorouracil to treat patients with human epidermal growth factor receptor 2 (HER2)-over expressing (also… HER2/neu gastric cancer, paraffin
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I AE1/AE3 TC
PAN (AE1/AE3) Cytokeratin, technical only PAN (AE1/AE3) Cytokeratin, technical only
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Translocation (11;18)(q21;q21) has been associated with extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). Translocation (11;18) leads to the fusion of the apoptosis inhibitor-2 (API2) gene and…
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Trisomy 13, trisomy 18 and trisomy 21, and numerical errors of the sex chromosomes (X and Y) constitute the most common chromosome abnormalities observed at prenatal diagnosis. DNA probes specific…
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The B-cell lymphoma 6 (BCL6) gene is localized to 3q27. Rearrangements of 3q27 may be seen in case diffuse large B-cell lymphoma (30-40%) and follicular lymphoma (5-15%). Structural rearrangements include…
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FP IGH MYC
The t(8;14)(q32;q24) joins the cellular oncogenes C-MYC with sequences from immunoglobulin heavy chain gene enhancers leading to deregulated expression of C-MYC protein. This abnormality is characteristic of Burkitt lymphoma and… IGH/MYC t(8;14)*, paraffin
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Sequence alterations of the EGFR gene have frequently been identified in non-small cell lung carcinoma (NSCLC), primarily in those patients who were responsive to Gefitinib, an EGFR tyrosine kinase inhibitor.…
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FP BCL2
BCL2 blocks apoptosis and maintains long-term immune responsiveness including B-cell memory. The most frequent non-random chromosome rearrangement in non-Hodgkin lymphoma (NHL) of B-cell type is t(14;18)(q32;q21), which is found in… IGH/BCL2 t(14;18), paraffin
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WT-1 tumor suppressor, by IHC, technical only
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E3 ubiquitin-protein ligase, technical only
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ATRX by Immunohistochemistry - technical only
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Rearrangements involving the IGH gene have been identified in about 50% of non-Hodgkin B-cell lymphomas (NHLs) and correlated to clinically relevant subgroups. A t(14;18)(q32;q21) is found in 88.1% of follicular…
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PTEN by Immunohistochemistry - technical only
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Cyclin-dependent kinase-4, technical only
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FP API MALT1
MALT lymphomas (also known as extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue) constitute about 8% of all non-Hodgkin lymphomas. The most common structural abnormality associated with MALT lymphomas… API2(BIRC3)/MALT1 t(11;18)*, paraffin
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Progesterone Receptor - Digital Image Analysis
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Deletions of chromosome 1p and 19q arms are frequent genetic abnormalities in primary human gliomas and are especially common in oligodendrogliomas. While 1p deletions are relatively common in other types…
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I PD-1 TC
Programmed death-1 immune response marker, technical only PD-1 protein, technical only
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Pan B cell, follicular dendritic cells, technical only
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Translocations of chromosome 8 are common aberrations in the B-cell non-Hodgkin lymphoma group. The presence of the typical t(8;14) or the rare variants t(8;22) and t(2;8) has been confirmed in…
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BL-CAM, integral membrane glycoprotein, Early B-cell, Hairy Cell leukemia [I CD22]
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I CD25 TC
Stains the alpha subunit of interleukin-2 receptor on the membrane of activated T cells CD25, technical only
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BL-CAM, Integral membrane glycoprotein, Early B-Cell, Hairy Cell Leukemia
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I CD25
Stains the alpha subunit of interleukin-2 receptor on the membrane of activated T cells CD25
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NSCLC,Cisplatin resistant cells; by IHC
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Apoptosis, cell cycle progression; by IHC
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