Testing

FP ROS1

ROS1 6q22.1 rearrangement by FISH

The LSI dual break-apart rearrangement probe contains two differently labelled probes on either sides of the breakpoint of the ROS1 gene. ROS1 has multiple fusion partners including but not limited…
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FP ALK

ALK 2p23 rearrangement, paraffin

The LSI dual break-apart rearragement probe contains two differently labelled probes on either sides of the breakpoint of the ALK gene. ALK has multiple fusion partners including NPM in anaplastic…
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FLOW M

Combined Flow Cytometry and Morphology Review

Combined Immunophenotyping, myeloid / lymphoid markers and Morphology review
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FP IGH MALT1

IGH/MALT1 t(14;18), paraffin

Translocation (11;18)(q21;q21) has been associated with extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). Translocation (11;18) leads to the fusion of the apoptosis inhibitor-2 (API2) gene and…
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FP MALT

MALT1 18q21 rearrangement, paraffin

FP HER2

HER2/neu breast cancer, paraffin

Her2/neu, also known as erbB2 or HER2, plays a key role in the regulation of cell growth. HER2 is over expressed through gene amplification in 25-30% of breast cancer patients.…
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FP BCL1

IGH/BCL1 (CCND1) t(11;14), paraffin

Mantle cell lymphoma can be difficult to distinguish morphologically from other B-cell malignant lymphomas. The translocation probe is designed to detect the juxtaposition of the IGH locus (14q32) next to…
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BMPE

Bone marrow pathology examination

Hematopathology
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FP HER2 GA

HER2/neu gastric cancer, paraffin

The FDA recently approved trastuzumab (Herceptin, Genentech) for use in combination with cisplatin and capecitabine or 5-fluorouracil to treat patients with human epidermal growth factor receptor 2 (HER2)-over expressing (also…
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FP BURKITT

Burkitt/”Double Hit” Large B-cell Lymphoma Panel, paraffin

This small, multiprobe panel contributes to the distinction of Burkitt’s from large B-cell lymphoma on problematic specimens demonstrating borderline morphologic or immunophenotypic features, limited sample volume, or zero to low…
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FP BCL6

BCL6 3q27 Rearrangement, paraffin

The B-cell lymphoma 6 (BCL6) gene is localized to 3q27. Rearrangements of 3q27 may be seen in case diffuse large B-cell lymphoma (30-40%) and follicular lymphoma (5-15%). Structural rearrangements include…
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FP GLIO MAP

Glioma FISH Panel, paraffin

Glioma FISH Panel, paraffin
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FP EGFR

EGFR amplification (7p11.2)*, paraffin

Sequence alterations of the EGFR gene have frequently been identified in non-small cell lung carcinoma (NSCLC), primarily in those patients who were responsive to Gefitinib, an EGFR tyrosine kinase inhibitor.…
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FP API MALT1

API2(BIRC3)/MALT1 t(11;18)*, paraffin

MALT lymphomas (also known as extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue) constitute about 8% of all non-Hodgkin lymphomas. The most common structural abnormality associated with MALT lymphomas…
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FP ANEU

Molar Pregnancy Panel +13, +18, +21,X,Y*, paraffin

Trisomy 13, trisomy 18 and trisomy 21, and numerical errors of the sex chromosomes (X and Y) constitute the most common chromosome abnormalities observed at prenatal diagnosis. DNA probes specific…
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FP BCL2

IGH/BCL2 t(14;18), paraffin

BCL2 blocks apoptosis and maintains long-term immune responsiveness including B-cell memory. The most frequent non-random chromosome rearrangement in non-Hodgkin lymphoma (NHL) of B-cell type is t(14;18)(q32;q21), which is found in…
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FP IGH MYC

IGH/MYC t(8;14)*, paraffin

The t(8;14)(q32;q24) joins the cellular oncogenes C-MYC with sequences from immunoglobulin heavy chain gene enhancers leading to deregulated expression of C-MYC protein. This abnormality is characteristic of Burkitt lymphoma and…
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FP IGH

IGH 14q32 Rearrangement*, paraffin

Rearrangements involving the IGH gene have been identified in about 50% of non-Hodgkin B-cell lymphomas (NHLs) and correlated to clinically relevant subgroups. A t(14;18)(q32;q21) is found in 88.1% of follicular…
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FP CMYC

C MYC 8q24 Rearrangement, paraffin

Translocations of chromosome 8 are common aberrations in the B-cell non-Hodgkin lymphoma group. The presence of the typical t(8;14) or the rare variants t(8;22) and t(2;8) has been confirmed in…
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