Test Name
Molar Pregnancy Panel +13, +18, +21,X,Y*, paraffin
Test Code
FP ANEU
Synonyms
13q14, CEP 18, 21q22.13, CEP X, CEP Y
Associations
Trisomy 13, trisomy 18, trisomy 21, aneuploidy X or Y
Molar Pregnancy
CPT Codes
88374, 88275, 88271, 88291
Turnaround Time
5
Specimen Requirements
FFPE tissue is acceptable for FISH analysis. Preferred fixative is 10% neutral buffered formalin. Tissues preserved in B5 fixative or decalcified are usually not suitable for FISH. Tumor sections cut 3-5 µm thick and mounted on positively charged organosilane coated (silanized) slides work well. Request several unstained sections (two for each probe) and one H&E stained slide
Specimen Stability
Stable indefinitely when stored at 20°C to 25°C
Storage & Handling
4°C to 25°C during transit, but specimens may be transported on refrigerated gel packs. Do not allow the gel pack to come in contact with the specimen. Do not freeze. Extreme temperatures should be avoided.
Causes for Rejections
Improper fixative; Tissue not fixed; Insufficient tissue; Specimen exposed to extreme temperature
Description
Trisomy 13, trisomy 18 and trisomy 21, and numerical errors of the sex chromosomes (X and Y) constitute the most common chromosome abnormalities observed at prenatal diagnosis. DNA probes specific for chromosomes 13, 18, 21, X and Y permit enumeration of
