Test Name
Glioma FISH Panel, paraffin
Test Code
FP GLIO MAP
Synonyms
[1p36-, 19q13- ; EGFR 7p11.2 amp.]
Associations
Oligodendroglioma
CPT Codes
88374 x2
Turnaround Time
3-5 days
Specimen Requirements
10% neutral buffered formalin fixed paraffin embedded tissue 5 mm^3 fresh tissue or 3.0 mL (min. 2.0 mL) FNA in MPLN RPMI media
Specimen Stability
Paraffin blocks stable at 18-25°C indefinitely Fresh tissue or FNA stable at 2-8°C for 72 hours
Storage & Handling
Fresh tissue, FNA or paraffin embedded tissue, ship in a Styrofoam container with a cool/refrigerated pack (Do not allow cool pack to directly contact sample)
Causes for Rejections
Improper fixative; Tissue not fixed; Insufficient tissue; Specimen exposed to extreme temperature
Description
Glioma FISH Panel, paraffin
References
- Law, Mark et al. (2006). Cancer Genetics and Cytogenetics. 160:1–14.
- Barbashina V et al. (2005). Allelic loss at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region at 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene. Clin Cancer Research. 11:1119.
- Smith JS et al. (2000). Alterations in chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas. J Clin Oncol. 18(3):636.
