Test Name
Warfarin Sensitivity Testing
Test Code
WARF*
Synonyms
WARF; CYP2C9 and VKORC1 allele testing
Associations
Cytochrome P450 (CYP2C9 or 2C9), Coumadin
CPT Codes
83891, 83896x11, 83908x3, 83912
Turnaround Time
2-3 days
Specimen Requirements
1.0 mL EDTA blood
Specimen Stability
Stable 4°C for up to 10 days
Storage & Handling
Ship with cool/refrigerated pack (Do not allow cool/refrigerated pack to directly contact sample)
Causes for Rejections
Less than 1.0 mL blood; Improper specimen labeling
Description
CYP2C9 and VKORC1 allele, Cytochrome P450 ,Coumadin
References
- McClain MR et al. (2008). A rapid ACCE review of CYP2C9 and VKORC1 allele testing to inform warfarin dosing in adults at elevated risk for thrombotic events to avoid serious bleeding. Genet Med. 10:89-98.
- Schwarz UI. (2008). Genetic determinants of response to warfarin during initial anticoagulation. NEJM. 358:999-1008.
