Test Name
UGT1A1 Genotype for Camptosar Toxicity
Test Code
UGT1A1*
Synonyms
Irinotecan toxicity
Associations
Metastatic colorectal cancer
CPT Codes
83891, 83892x8, 83896x12, 83903x4, 83908x4, 83912-
Specimen Requirements
5.0 mL (min. 3.0 mL) whole blood EDTA, ACD accepted.
Specimen Stability
Stable at 18°-25°C for 24 hours Stable 4°C for up to 4 days
Storage & Handling
Ship at ambient temperature If shipment delayed, store at 2–8°C, and ship with cool/refrigerated pack (Do not allow cool/refrigerated pack to directly contact sample)
Causes for Rejections
Clotted specimen; Specimen exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells
References
- Food and Drug Administration; Background document on UGT1A1 polymorphisms and irinotecan toxicity
- Innocenti F et al. (2004). Genetic variants in the UDP-glucuronasyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan. J Clin Oncol. 22(8):1382-1388.
