Test Name
IDH2 Mutation Analysis
Test Code
M IDH2
Associations
IDH mutations are recurrent in a variety of cancer settings including glial neoplasms, acute myeloid leukemias, cholangiocarcinomas, and chondrosarcomas, among others.
CPT Codes
81121
Turnaround Time
10 days
Specimen Requirements
Formalin Fixed Paraffin Embedded tissue block 3 slides (3-5 uM) per marker on adhesion glass NOTE: Include a surgical pathology report with the sample if sending a block and/or slides 5.0 mL (min. 3.0 mL) whole blood EDTA, Sodium Heparin or ACD 3.0 mL (min. 1.0 mL) bone marrow EDTA, Sodium Heparin or ACD
Specimen Stability
Indefinite at ambient temperature (18-25°C) Whole blood and Bone Marrow stable at 18-25°C for 72 hours or 4°C for up to 7 days
Storage & Handling
Ship ambient. Protect from extreme temperature with an ice pack. Separate ice pack from specimen
Causes for Rejections
Improper specimen labeling; Insufficient sample volume; Clotted specimen; Specimen older than 7 days
Description
Targeted next generation sequencing is performed to asses for the following pathogenic hotspot mutations: IDH2 p.R140 and IDH2p.R172.
