Test Name
ABL Kinase Gene Mutation Analysis
Test Code
M ABL G*
Synonyms
ABL kinase domain gene sequencing
Associations
chronic myelogenous leukemia (CML), acute lymphoblastic leukemia (ALL), allogeneic bone marrow transplantation, minimal residual disease (MRD), molecular remission, Gleevec® resistance
Turnaround Time
14 days
Specimen Requirements
10.0 mL (min. 9.0 mL) peripheral blood in EDTA 2.0 mL (min. 1.0 mL) bone marrow in EDTA
Specimen Stability
Specimen must be received by MPLN within 36 hours of collection Stable at 2-8°C
Storage & Handling
Ship peripheral blood and bone marrow at refrigerated temperature. Please notify us if specimen is to arrive after 1 p.m. on Friday or Saturday.
Causes for Rejections
Specimen > 48 hours old; Specimen clotted; Stored or shipped at incorrect temperature; Incorrect anticoagulant; Insufficient specimen volume
Description
MolecularMD has designed and validated bi-directional Sanger sequencing assays to identify mutations in the p210 and p190 transcripts of the BCR-ABL1 fusion gene. Our assay spans an extended region including the kinase and SH2-SH3 regulatory domains and i
References
- Cell Cycle 2011; 10:250-260 2. Blood 2011; 116:3278-3285
