Test Name
MYB 6q deletion
Test Code
F MYB
Synonyms
deletion 6q23, del(6)(q23)
Associations
Chronic lymphocytic leukemia (CLL), Childhood acute lymphoblastic leukemia (ALL), B-cell small lymphocytic lymphoma (SLL), Plasma cell myeloma
CPT Codes
88374
Turnaround Time
5
Specimen Requirements
5mL peripheral blood in sodium heparin 3mL bone marrow in sodium heparin Fixed cytogenetically prepared cells in sterile centrifuge tube with pellet visible in 3:1, Methanol:Acetic Acid
Specimen Stability
Blood and bone marrow = 4°C to 25°C, specimens are stable up to 72 hours Fixed cell pellets are stable for years when stored at -28°C to -15°C
Storage & Handling
4°C to 25°C during transit, but specimens may be transported on refrigerated gel packs. Do not allow the gel pack to come in contact with the specimen. Do not freeze. Extreme temperatures should be avoided.
Causes for Rejections
Clotted specimen; Specimen exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells
Description
This abnormality has been associated with childhood acute lymphoblastic leukemia (ALL), adult ALL, B-cell small lymphocytic lymphoma, atypical chronic lymphocytic leukemia and plasma cell myeloma. FISH can detect this rearrangement in either interphase or
References
- Letter to the editor. (2003). Cancer Genetics and Cytogenetics. 143 87–88.
- Brigaudeau C and Bilhou-Nabera C.(1998). del(6q) abnormalities in lymphoid malignancies. Atlas Genet Cytogenet Oncol Haematol. December.
- Brigaudeau C. (1988) del(6q) in Multiple Myeloma. Atlas Genet Cytogenet Oncol Haematol. September.
