Test Name
Myelodsyplasia Panel (MDS)
Test Code
F MDS
Synonyms
EGR1 -5 /5q-, -7/7q-, +8, 20q-
Associations
Myelodsyplasia (MDS)
CPT Codes
88374 x4
Turnaround Time
5
Specimen Requirements
5mL peripheral blood in sodium heparin 3mL bone marrow in sodium heparin Fixed cytogenetically prepared cells in sterile centrifuge tube with pellet visible in 3:1, Methanol:Acetic Acid
Specimen Stability
Blood and bone marrow = 4°C to 25°C, specimens are stable up to 72 hours Fixed cell pellets are stable for years when stored at -28°C to -15°C
Storage & Handling
4°C to 25°C during transit, but specimens may be transported on refrigerated gel packs. Do not allow the gel pack to come in contact with the specimen. Do not freeze. Extreme temperatures should be avoided.
Causes for Rejections
Clotted specimen; Specimens exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells;
Description
Clonal chromosome abnormalities are found at diagnosis in about 60% of patients with de novo MDS and almost 85% of those with AML or secondary MDS. The FISH profile used for detection of chromosome abnormalities in MDS and AML includes probes for chromoso
References
- Look A.T. (2005). Molecular Pathogenesis of MDS. Hematology. 1:156.
- Hofmann WK et al. (1996). Myelodysplastic syndromes: clinical features. Semin Hematol. 33(3):177.
- Flandrin G. (2002). Classification of myelodysplastic syndromes. Atlas Genet Cytogenet Oncol Haematol.
