Test Name
BCL2, IGH/BCL2 t(14;18)
Test Code
F BCL2
Synonyms
IGH/BCL2; t(14;18)(q32;q21)
Associations
B-cell lymphoma (BCL), Non-Hodgkin lymphoma (NHL), Follicular lymphoma (FCL);
Tyrosine kinase inibitors
CPT Codes
88374
Turnaround Time
3-5 days
Specimen Requirements
F BCL2 2.0 mL (min. 1.0 mL) peripheral blood in sodium heparin, EDTA accepted 1.0 mL (min. 0.5 mL) bone marrow in sodium heparin, EDTA accepted 5 mm^3 fresh tissue or 3.0 mL (min. 2.0 mL) FNA in MPLN RPMI media FP BCL2 10% neutral buffered formalin fixed paraffin embedded tissue (FFPE)
Specimen Stability
Peripheral blood and bone marrow stable at 18-25°C for 72 hours Fresh tissue or FNA stable at 2-8°C for 72 hours FFPE stable stable indefinitely
Storage & Handling
Whole blood and bone marrow, ship ambient Fresh tissue, FNA or FFPE ship in a Styrofoam container with a cool/refrigerated pack (Do not allow cool pack to directly contact sample)
Causes for Rejections
Clotted specimen; Specimen exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells; Improper fixative
Description
NHL; by FISH
References
- Noreiga M et al. (2004). Blood Cells, Molecules and Diseases. Volume 32, Issue 1. 232-239.
- Vaandrager J et al. (2000). Genes Chrom Cancer. 25:85-94.
