Test Name
API2(BIRC3)/MALT1 t(11;18)*
Test Code
F API MALT
Synonyms
t(11;18)(q22;q21), MALT lymphoma, Mucosa associated lymphoid tissue translocation gene 1
Associations
MALT lymphoma, Non-Hodgkin (NHL), Extranodal marginal zone B-cell lymphoma
CPT Codes
88374
Turnaround Time
5
Specimen Requirements
5mL peripheral blood in sodium heparin 3mL bone marrow in sodium heparin Fixed cytogenetically prepared cells in sterile centrifuge tube with pellet visible in 3:1, Methanol:Acetic Acid
Specimen Stability
Blood and bone marrow = 4°C to 25°C, specimens are stable up to 72 hours Fixed cell pellets are stable for years when stored at -28°C to -15°C
Storage & Handling
4°C to 25°C during transit, but specimens may be transported on refrigerated gel packs. Do not allow the gel pack to come in contact with the specimen. Do not freeze. Extreme temperatures should be avoided.
Causes for Rejections
Clotted specimen; Specimen exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells; Improper fixative
Description
MALT lymphomas (also known as extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue) constitute about 8% of all non-Hodgkin lymphomas. The most common structural abnormality associated with MALT lymphomas is the translocation betwe
References
- Mathijs B, Marynen P. (2001). t(11;18)(q21;q21). Atlas Genet Cytogenet Oncol Haematol. http://atlasgeneticsoncology.org/Anomalies/t1118ID2022.html
- Bertoni F et al. (2006). Delving deeper into MALT lymphoma biology. J Clin Invest. 116(1):22.
- Cavalli F et al. (2001). MALT lymphomas. Hematology.(1):241.
- Streubel B et al. (2003). t(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma. Blood. 101(6):2335.
