Test Name
Chromosome Analysis Leukemic Peripheral Blood (Oncology)
Test Code
CYTO LPB
Synonyms
Chromosome analysis, cytogenetic analysis, karyotyping
Associations
Leukemia
CPT Codes
By report 88237, 88264, 88280xn, 88291
Turnaround Time
7
Specimen Requirements
5 mL sodium heparin tube 1 mL (newborn blood) 2 mL (percutaneous umbilical blood) Fixed cytogenetically prepared cells in sterile centrifuge tube with 3:1, Methanol:Acetic Acid. Pellet must be visible for the volume part and the medium part 3:1, Methanol:Acetic Acid.
Specimen Stability
4°C to 25°C, specimens (peripheral blood) are stable up to 72 hours Fixed cell pellets are stable for years when stored at -28 °C to -15 °C
Storage & Handling
4°C to 25°C during transit, but specimens may be transported on refrigerated gel packs. Do not allow the gel pack to come in contact with the specimen. Do not freeze. Extreme temperatures should be avoided.
Causes for Rejections
Clotted specimen; Specimen exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells
Description
In hematological malignant diseases, recognized recurring chromosomal abnormalities often correlate with particular subtypes of leukemia that have characteristic morphological and clinical features, such as response to therapy. The study of chromosomal ab
References
- Barch M. (1991). The ACT Cytogenetic Laboratory Manual. 2nd edition, 395-396.
- Dunn B. (2005). The Cytogenetic Symposia. 2nd edition, 13-1.
- Kaplan B. (1994). The Cytogenetic Symposia. 8-1.
