Test Name
Human Papillomavirus Genotype
Test Code
HPV G
Associations
In 2013 Hologic's APTIMA® HPV 16 18/45 genotype assay was FDA‐approved for genotyping human papillomavirus (HPV) types 16, 18 and/or 45. HPV genotype 45 is the third most common HPV genotype in invasive cancer. The addition of HPV genotype 45
CPT Codes
87625
Turnaround Time
3-5 days
Specimen Requirements
2.0 mL liquid cytology media (ThinPrep® PAP solution or SurePath™ Test Pack solution)
Specimen Stability
ThinPrep/SurePath - 30 days from collection at 18-25°C. Specimens are kept for 21 days after receipt
Storage & Handling
Ship at ambient
Causes for Rejections
Insufficient specimen; Low sample cellularity
Description
To be used adjunctively, with an FDA approved HPV high risk test, in patients with either a HPV HR+ ASC-US result or, in women 30 years of age and older, with a HPV HR+ primary screening result.
References
- American Society for Colposcopy and Cervical Pathology
- Meijer CJ et al. (2006). Clinical utility of HPV genotyping. Gynecol Oncol. 103:12-17.
- Khan MJ et al. (2005). The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice. JNCI. 97:1072-1079.
- Munoz N et al. (2003). Epidemiologic classification of human papillomavirus types associated with cervical cancer. NEJM. 348:518-527.
