Test Name
Leukocyte Adhesion Deficiency
Test Code
FLOW LAD
Synonyms
Beta 2 integrins; LAD I; LAD II
Associations
Type I and II leukocyte adhesion deficiency. Panel measures CD11b, CD15, and CD18 on neutrophils.
Reflex Testing
None
CPT Codes
88184, 88185x7, 88187
Turnaround Time
3
Specimen Requirements
Whole blood: 5 mL (min. 1 mL) sodium heparin or lithium heparin
Specimen Stability
Specimen stable for 48 hours at 4°C
Storage & Handling
Ship refrigerated. Protect from extreme temperature. Separate ice pack from specimen.
Causes for Rejections
Clotted specimens. Frozen or room temperature specimens. Specimens greater than 48 hours.
Description
CD11a, CD11b, CD11c, CD16, CD18, CD14, CD15, CD45
References
- Nervi SJ et al. (2007). Leukocyte Adhesion Deficiency. eMedicine.
- Cox et al. (2007). Leukocyte adhesion deficiency type 1: an important consideration in the clinical differential diagnosis of prepubertal periodontitis. a case report and review of the literature. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology.
- Hann et al. (2006). Pediatric Hematology. Blackwell Publishing.
- Lichtman et al. (2006). Hematology, 7th edition. McGraw-Hill Companies, Inc. 935-938.
- Nervi SJ (2006). Leukocyte Adhesion Deficiency. eMedicine.
- Etzioni A. (2005). Leukocyte Adhesion Deficiency (LAD) Syndromes. Orphanet Encyclopedia.
- Keren et al. (2001). Flow Cytometry in Clinical Diagnosis 3rd edition. ASCP Press.
