Test Name
FIP1L1/PDGFRA 4q12 Rearrangement
Test Code
F 4Q12
Synonyms
4q12 rearrangement, CHIC2/F1LP1L1/PDGFRα, platelet-derived growth factor receptor-α
Associations
Hypereosinophilia, Mast cell
CPT Codes
88374
Turnaround Time
3-5 days
Specimen Requirements
5mL peripheral blood in sodium heparin 3mL bone marrow in sodium heparin Fixed cytogenetically prepared cells in sterile centrifuge tube with pellet visible in 3:1, Methanol:Acetic Acid
Specimen Stability
Blood and bone marrow = 4°C to 25°C, specimens are stable up to 72 hours Fixed cell pellets are stable for years when stored at -28°C to -15°C
Storage & Handling
4°C to 25°C during transit, but specimens may be transported on refrigerated gel packs. Do not allow the gel pack to come in contact with the specimen. Do not freeze. Extreme temperatures should be avoided.
Causes for Rejections
Clotted specimen; Specimen exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells; Improper fixative
Description
FIP1L1/PDGFRA 4q12 Gene Rearrangement
References
- Buitenhuis M et al. (2007). Cancer Res. 67:(8) April 15.
