Test Name
SRY/CEP X*
Test Code
F SRY
Synonyms
SRY region, Yp11.3/Xp11.1q11.1
Associations
Bone marrow, stem cell transplant
CPT Codes
88377 OR 88275x2, 88271x2, 88291x1
Turnaround Time
9
Specimen Requirements
2.0 mL (min. 1.0 mL) peripheral blood in sodium heparin preferred, EDTA accepted 1.0 mL (min. 0.5 mL) bone marrow in sodium heparin preferred, EDTA accepted 5 mm^3 fresh tissue in MPLN RPMI media 3.0 mL (min. 2.0 mL) FNA in MPLN RPMI media 10% neutral buffered formalin fixed paraffin embedded tissue
Specimen Stability
Peripheral blood and bone marrow stable at 4-25°C for 72 hours Fresh tissue or FNA stable at 2-8°C for 72 hours
Storage & Handling
Peripheral blood and bone marrow, Ship with cool pack (refrigerated). Fresh tissue, FNA or paraffin embedded tissue, ship in a Styrofoam container with a cool/refrigerated pack. (Do not allow cool pack to directly contact sample.)
Causes for Rejections
Clotted specimen; Specimen exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells; Improper fixative
Description
del Yp11.3; post sex mismatched transplantation; by FISH
References
- Theide C. (2004). Diagnostic chimerism analysis after allogeneic stem cell transplantation: new methods and markers. Am J Pharmocogenomics. 4(3):177.
- Tamura S et al. (2000). Early detection of relapse and evaluation of treatment for mixed chimerism using fluorescence in situ hybridization following allogeneic hematopoietic cell transplant for hematological malignancies. Ann Hematol. 79(11):622.
